Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly Ambiguous HIV-1 Pol Positions Encoding Multiple Amino Acids Usually Result from Antiviral or Immune Selection Pressure.

AIDS research and human retroviruses - 1 Mar 2023

Tao Kaiming, Rhee Soo-Yon, Tzou Philip L, Holmes Susan P, Shafer Robert W

Abstract excerpt

HIV-1 pol nucleotide ambiguities encoding amino acid mixtures occur commonly during population-based genotypic drug resistance testing. However, few studies have addressed the validity of sequences with fully ambiguous codons (FACs) containing codons translatable to more than four amino acids. We identified 839 published HIV-1 pol sequences with 846 FACs at 131 positions and determined their distribution relative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Anti-HIV Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antiviral Agents

Share to Drug Resistance, Viral

Share to HIV Protease

Share to HIV Reverse Transcriptase

Share to HIV Seropositivity

Source

Open in PubMed Open full text

Identifiers

PMID: 36515174
DOI: 10.1089/AID.2022.0094
PMCID: PMC9986027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly Ambiguous HIV-1 Pol Positions Encoding Multiple Amino Acids Usually Result from Antiviral or Immune Selection Pressure.PMID 36515174Read ↗

Evaluation of sequence ambiguities of the HIV-1 pol gene as a method to identify recent HIV-1 infection in transmitted drug resistance surveysSemantic proximity Read ↗

Synonymous-non-synonymous mutation rates between sequences containing ambiguous nucleotides (Syn-SCAN).Semantic proximity Read ↗

Analysis of unusual and signature APOBEC-mutations in HIV-1 pol next-generation sequences.Semantic proximity Read ↗

Molecular characterization of ambiguous mutations in HIV-1 polymerase gene: implications for monitoring HIV infection status and drug resistance.Semantic proximity Read ↗

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Semantic proximity Read ↗

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.Semantic proximity Read ↗

Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol ProteinsSemantic proximity Read ↗

Peptide insertions in reverse transcriptase pol gene of human immunodeficiency virus type 1 as a rare cause of persistent antiretroviral therapeutic failure.Semantic proximity Read ↗

Structural analysis of reverse transcriptase mutations at codon 215 explains the predominance of T215Y over T215F in HIV-1 variants selected under antiretroviral therapy.Semantic proximity Read ↗

Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy.Semantic proximity Read ↗

Assessment of ambiguous base calls in HIV-1 pol population sequences as a biomarker for identification of recent infections in HIV-1 incidence studies.Semantic proximity Read ↗

Interpretation systems for genotypic drug resistance of HIV-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.