Article
Molecular characterization of ambiguous mutations in HIV-1 polymerase gene: implications for monitoring HIV infection status and drug resistance.
PloS one - 1 Jan 2013
Zheng Du-Ping, Rodrigues Margarida, Bile Ebi, Nguyen Duc B, Diallo Karidia, DeVos Joshua R, Nkengasong John N, Yang Chunfu
Abstract excerpt
Detection of recent HIV infections is a prerequisite for reliable estimations of transmitted HIV drug resistance (t-HIVDR) and incidence. However, accurately identifying recent HIV infection is challenging due partially to the limitations of current serological tests. Ambiguous nucleotides are newly emerged mutations in quasispecies, and accumulate by time of viral infection. We utilized ambiguous mutations to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.