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Article

Assessment of ambiguous base calls in HIV-1 pol population sequences as a biomarker for identification of recent infections in HIV-1 incidence studies.

Journal of clinical microbiology - 1 Aug 2014

Meixenberger Karolin, Hauser Andrea, Jansen Klaus, Yousef Kaveh Pouran, Fiedler Stefan, von Kleist Max, Norley Stephen, Somogyi Sybille, Hamouda Osamah, Bannert Norbert, Bartmeyer Barbara, Kücherer Claudia

Abstract excerpt

An increase in the proportion of ambiguous base calls in HIV-1 pol population sequences during the course of infection has been demonstrated in different study populations, and sequence ambiguity thresholds to classify infections as recent or nonrecent have been suggested. The aim of our study was to evaluate sequence ambiguities as a candidate biomarker for use in an HIV-1 incidence assay using samples from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24920768
DOI: 10.1128/JCM.03289-13
PMCID: PMC4136167

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