Article
Interpretation systems for genotypic drug resistance of HIV-1.
Scandinavian journal of infectious diseases. Supplementum - 1 Jan 2003
De Luca Andrea, Antinori Andrea, Di Giambenedetto Simona, Cingolani Antonella, Colafigli Manuela, Perno Carlo Federico, Cauda Roberto
Abstract excerpt
Genotypic assays are widely used tools for determining human immunodeficiency virus type 1 (HIV-1) drug resistance and for guiding treatment changes in patients failing antiretroviral therapy. Several systems have been developed to interpret the complex influence of key amino acid substitutions of the enzymes targeted by therapy on the phenotypic susceptibility or clinical response to available antiretroviral...
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