Article
Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy.
Antiviral therapy - 1 Apr 2003
Brumme Zabrina L, Chan Keith J, Dong Winnie W Y, Wynhoven Brian, Mo Theresa, Hogg Robert S, Montaner Julio S G, O'Shaughnessy Michael V, Harrigan P Richard
Abstract excerpt
We assessed the prevalence and clinical impact of insertions within the HIV-1 p6Gag proline-rich (PTAP) region on initial antiretroviral therapy response in 461 HIV-infected, drug-naive individuals initiating therapy in British Columbia, Canada between June 1996 and August 1998. HIV p6Gag insertions were detected by nested RT-PCR of extracted patient plasma followed by direct DNA sequencing. Insertions were...
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