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Article

The emerging role of speckle-type POZ protein (SPOP) in cancer development.

Drug discovery today - 1 Sept 2014

Mani Ram-Shankar

Abstract excerpt

Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25058385
DOI: 10.1016/j.drudis.2014.07.009
PMCID: PMC4237012

Genes

SPOP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The emerging role of speckle-type POZ protein (SPOP) in cancer development.PMID 25058385Read ↗

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Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer.Semantic proximity Read ↗

Speckle-type POZ protein mutations in prostate cancer: a new part of the mosaic.Semantic proximity Read ↗

Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation.Semantic proximity Read ↗

Updates on SPOP Gene Mutations in Prostate Cancer and Computational Insights From TCGA cBioPortal DatabaseSemantic proximity Read ↗

The emerging role of SPOP protein in tumorigenesis and cancer therapy.Semantic proximity Read ↗

Identification of speckle-type POZ protein somatic mutations in African American prostate cancer.Semantic proximity Read ↗

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Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.Semantic proximity Read ↗

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover.Semantic proximity Read ↗

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