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Article

Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2018

Witten Anika, Bolbrinker Juliane, Barysenka Andrei, Huber Matthias, Rühle Frank, Nowak-Göttl Ulrike, Garbe Edeltraut, Kreutz Reinhold, Stoll Monika

Abstract excerpt

Immune-mediated heparin-induced thrombocytopenia (HIT) is the clinically most important adverse drug reaction (ADR) in response to heparin therapy characterized by a prothrombotic state despite a decrease in platelet count. We conducted a genome-wide association study in 96 suspected HIT cases and 96 controls to explore the genetic predisposition for HIT within a case-control pharmacovigilance study followed by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29934777
DOI: 10.1007/s00109-018-1661-6

Genes

ADAMTS16
DDR1
ICE1
MCTP2
ELL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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