Article
SETD2 histone modifier loss in aggressive GI stromal tumours.
Gut - 1 Dec 2016
Huang Kie Kyon, McPherson John R, Tay Su Ting, Das Kakoli, Tan Iain Beehuat, Ng Cedric Chuan Young, Chia Na-Yu, Zhang Shen Li, Myint Swe Swe, Hu Longyu, Rajasegaran Vikneswari, Huang Dachuan, Loh Jia Liang, Gan Anna, Sairi Alisa Noor Hidayah, Sam Xin Xiu, Dominguez Lourdes Trinidad, Lee Minghui, Soo Khee Chee, Ooi London Lucien Peng Jin, Ong Hock Soo, Chung Alexander, Chow Pierce Kah-Hoe, Wong Wai Keong, Selvarajan Sathiyamoorthy, Ong Choon Kiat, Lim Kiat Hon, Nandi Tannistha, Rozen Steve, Teh Bin Tean, Quek Richard, Tan Patrick
Abstract excerpt
BACKGROUND: GI stromal tumours (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients. OBJECTIVES: We sought to identify genetic alterations associated with high-risk GIST, explore their molecular consequences, and test their utility as prognostic markers. DESIGNS: Exome sequencing of 18 GISTs was performed (9 patients with high-risk/metastatic and 5...
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