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Distinct Molecular and Prognostic Profiles of Left- and Right-Sided Colorectal Cancer Revealed by NGS Analysis: The Role of SMAD4 and SETD2 Mutations.

Cancer medicine - 1 Jan 2026

Zhao Wenlei, Qiu Yuxuan, Bai Na, He Chunhong, Yin Jiani C, Xu Qianru, Jian Kaiyu, Jia Baolei, Jiang Lin, Liang Feng

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) isthe third most common cancer and the second leading cause of cancer-relateddeath worldwide. Its genetic heterogeneity complicates treatment. This studyaimed to compare clinicopathological, molecular, and prognostic factors betweenleft-sided (LCC) and right-sided (RCC) CRC. METHODS: We retrospectively analyzed 48 CRCpatients who received next-generation sequencing (NGS) of...

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Source

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Identifiers

PMID: 41562159
DOI: 10.1002/cam4.71534
PMCID: PMC12820718

Genes

SETD2
SMAD4
ARID1A
BRAF
PRDM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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