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Effects of KMT2D mutation and its exon 39 mutation on the immune microenvironment and drug sensitivity in colorectal adenocarcinoma

1 Feb 2023

Abstract excerpt

Background KMT2D mutation (KMT2D MT ) was found to play an important role in cancer immunity and response to immune checkpoint inhibitors (ICIs). The present study aims to investigate the association between KMT2D exon 39 mutation (K-ex39 MT ) and molecular and clinical characteristics in colorectal adenocarcinoma (CRAD). Methods We performed profiling of KMT2D MT and K-ex39 MT via Kaplan–Meier analysis,...

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PMID: 36846668
DOI: 10.1016/j.heliyon.2023.e13629

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