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Article

Correlation of KMT2 family mutations with molecular characteristics and prognosis in colorectal cancer.

The International journal of biological markers - 1 Jun 2022

Liao Cun, Huang Wei, Lin Minglin, Li Hui, Zhang Zihan, Zhang Xiaolong, Chen Rongrong, Huang Mingfeng, Yu Pengli, Zhang Sen

Abstract excerpt

BACKGROUND: Lysine methyltransferase 2 (KMT2) family proteins methylate lysine 4 on histone H3 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of KMT2 family have been observed frequently in various types of human cancers. Colorectal cancer is the third most common cancer worldwide. However, few studies have evaluated the role of KMT2 family mutations in colorectal cancer. The...

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PMID: 35505597
DOI: 10.1177/03936155221095574

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