Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in the STHdh Cell Model of Huntington Disease.

International journal of molecular sciences - 5 Dec 2022

Cattaneo Monica, Maciag Anna, Milella Maria Serena, Ciaglia Elena, Bruno Antonino, Puca Annibale Alessandro

Abstract excerpt

Huntington's disease (HD) is caused by the production of mutant Huntingtin (mHTT), characterized by long polyglutamine repeats with toxic effects. There are currently no clinically validated therapeutic agents that slow or halt HD progression, resulting in a significant clinical unmet need. The striatum-derived STHdh cell line, generated from mHTT knock-in mouse embryos (STHdhQ111/Q111), represents a useful model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Huntingtin Protein

Share to Huntington Disease

Share to Neostriatum

Share to Neuroprotection

Source

Open in PubMed Open full text

Identifiers

PMID: 36499641
DOI: 10.3390/ijms232315313
PMCID: PMC9737551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in the STHdh Cell Model of Huntington Disease.PMID 36499641Read ↗

Huntington's disease: the coming of age.Semantic proximity Read ↗

Molecular Strategies for the Treatment of Huntington's Disease.Semantic proximity Read ↗

The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.Semantic proximity Read ↗

Therapeutics Advancement for Huntington DiseaseSemantic proximity Read ↗

METTL3-IGF2BP3 m⁶A axis drives mutant huntingtin stability and neurodegeneration in Huntington’s diseaseSemantic proximity Read ↗

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s diseaseSemantic proximity Read ↗

Therapeutic Advances for Huntington’s DiseaseSemantic proximity Read ↗

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington's disease.Semantic proximity Read ↗

Recent approaches on Huntington's disease (Review)Semantic proximity Read ↗

Huntington's disease: progress toward effective disease-modifying treatments and a cure.Semantic proximity Read ↗

Molecular Pathogenesis in Huntington’s DiseaseSemantic proximity Read ↗

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.