Article
The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.
Cell death & disease - 18 Jul 2020
Di Pardo Alba, Ciaglia Elena, Cattaneo Monica, Maciag Anna, Montella Francesco, Lopardo Valentina, Ferrario Anna, Villa Francesco, Madonna Michele, Amico Enrico, Carrizzo Albino, Damato Antonio, Pepe Giuseppe, Marracino Federico, Auricchio Alberto, Vecchione Carmine, Maglione Vittorio, Puca Annibale A
Abstract excerpt
The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington's disease (HD), a neurodegenerative disorder caused by neural death due to expanded CAG repeats encoding a long polyglutamine tract in the huntingtin protein (Htt). Herein, we...
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