Back to search

Article

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s disease

2025-03-13

Abstract excerpt

Huntington’s disease (HD) is a debilitating hereditary movement disorder caused by a CAG repeat expansion in the huntingtin gene. HD is characterized by deposition of mutant huntingtin (mHTT) aggregates, and by severe neurodegeneration of the basal ganglia and neocortex. No cure is currently available, and new treatment options are urgently needed. Here, we show that the oligomer modifying molecule anle138b (INN:...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8b5792ff-1204-57ed-b503-7fa55e471791
DOI
10.1101/2025.03.11.642540
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s diseaseDOI 10.1101/2025.03.11.642540
Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington's disease.Semantic proximity
Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.Semantic proximity
The Emerging Landscape of Small-Molecule Therapeutics for the Treatment of Huntington’s DiseaseSemantic proximity
From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease ResearchSemantic proximity
Huntington's disease: a clinical reviewSemantic proximity
Emerging therapies in Huntington’s diseaseSemantic proximity
Huntington's disease: progress toward effective disease-modifying treatments and a cure.Semantic proximity
Huntington’s Disease: From Genetics to TherapeuticsSemantic proximity
Recent approaches on Huntington's disease (Review)Semantic proximity
Therapeutics Advancement for Huntington DiseaseSemantic proximity
Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's diseaseSemantic proximity
Therapeutic Advances for Huntington’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.