Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRIM15 drives chondrocyte senescence and osteoarthritis progression

26 Mar 2025

Abstract excerpt

Osteoarthritis (OA) is a prevalent joint disease characterized by pain, disability, and loss of physical function, posing a challenge to public health. However, molecular mechanisms of OA pathogenesis have not been fully described. We report that tripartite motif containing 15 (TRIM15) is a regulator in chondrocyte senescence and OA. Our study revealed heightened expression of TRIM15 in chondrocytes of senescent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Osteoarthritis Treatment and Mechanisms
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40138455
DOI: 10.1126/scitranslmed.adq1735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRIM15 drives chondrocyte senescence and osteoarthritis progressionPMID 40138455Read ↗

Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in OsteoarthritisSemantic proximity Read ↗

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescenceSemantic proximity Read ↗

Sirt6 attenuates chondrocyte senescence and osteoarthritis progressionSemantic proximity Read ↗

Reciprocal Regulation between lncRNA ANRIL and p15 in Steroid-Induced GlaucomaSemantic proximity Read ↗

BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in miceSemantic proximity Read ↗

Bioinformatic analysis reveals potential relationship between chondrocyte senescence and protein glycosylation in osteoarthritis pathogenesisSemantic proximity Read ↗

Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritisSemantic proximity Read ↗

H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasisSemantic proximity Read ↗

TMEM2-mediated hyaluronan turnover maintains articular cartilage homeostasis during osteoarthritis progressionSemantic proximity Read ↗

Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritisSemantic proximity Read ↗

The ganglioside GD3 and its Synthase (ST8SIA1) as novel senescence markers associated with osteoarthritisSemantic proximity Read ↗

miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte SenescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.