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Article

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence

29 May 2024

Abstract excerpt

BACKGROUND: Due to the unclear pathogenesis of osteoarthritis (OA), effective treatment for this ailment is presently unavailable. Accumulating evidence points to chondrocyte senescence as a key driver in OA development. This study aims to identify OA-specific microRNAs (miRNAs) targeting chondrocyte senescence to alleviate OA progression. METHODS: We screened and identified miRNAs differentially expressed in OA...

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PMID: 38812033
DOI: 10.1186/s13075-024-03334-5

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