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Human Leukocyte Antigen B14:01 and B35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury.

Hepatology (Baltimore, Md.) - 1 Jan 2021

Li Yi-Ju, Phillips Elizabeth J, Dellinger Andrew, Nicoletti Paola, Schutte Ryan, Li Danmeng, Ostrov David A, Fontana Robert J, Watkins Paul B, Stolz Andrew, Daly Ann K, Aithal Guruprasad P, Barnhart Huiman, Chalasani Naga

Abstract excerpt

BACKGROUND AND AIMS: Trimethoprim (TMP)-sulfamethoxazole (SMX) is an important cause of idiosyncratic drug-induced liver injury (DILI), but its genetic risk factors are not well understood. This study investigated the relationship between variants in the human leukocyte antigen (HLA) class 1 and 2 genes and well-characterized cases of TMP-SMX DILI. APPROACH AND RESULTS: European American and African American...

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PMID: 32270503
DOI: 10.1002/hep.31258
PMCID: PMC7544638

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