Article
BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2023
Choi Eun, Mun Gil-Im, Lee Joohyun, Lee Hanhee, Cho Jaeho, Lee Yun-Sil
Abstract excerpt
Mutations in breast cancer-associated 1 (BRCA1) increase the lifetime risk of developing breast cancer by up to 51% over the risk of the general population. Many aspects of this multifunctional protein have been revealed, including its essential role in homologous recombination repair, E3 ubiquitin ligase activity, transcriptional regulation, and apoptosis. Although most studies have focused on BRCA1 deficiency...
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