[BRCA1 Gene's Mutations And Hereditary Breast Cancer: Genetic, Biological, And Clinical Aspects].

Abstract excerpt

Introduction: Hereditary breast cancer accounts for approximately 5 to 10% of all breast cancer cases. Mutations in the BRCA1 gene, which plays a central role in DNA repair and cell cycle regulation, are the main cause of these familial forms and are strongly associated with aggressive subtypes, particularly triple-negative breast cancer. Methods: A narrative literature review was conducted using biomedical...

Topics

• Humans
• Female
• Breast Neoplasms
• Genetic Predisposition to Disease
• Genes, BRCA1
• Mutation
• BRCA1 Protein