Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers.

Abstract excerpt

ABSTRACT: Thirty years ago, the cloning of the first breast cancer susceptibility gene, BRCA1, marked a milestone in our understanding of hereditary breast and ovarian cancers. This discovery initiated extensive research into DNA repair mechanisms, BRCA1-associated tumorigenesis, and therapeutic interventions. Despite these advances, critical questions remain unanswered, such as the evolution of BRCA1-associated...

Topics

• Female
• Humans
• BRCA1 Protein
• Breast Neoplasms
• Genetic Predisposition to Disease
• Heterozygote
• Mutation