BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications.

Abstract excerpt

Mutations in the tumor suppressor breast cancer susceptibility gene 1 (BRCA1), an important player in the DNA damage response, apoptosis, cell cycle regulation and transcription, confer a significantly elevated lifetime risk for breast and ovarian cancer. Although the loss of wild-type BRCA1 function is an important mechanism by which mutations confer increased cancer risk, multiple studies suggest mutant BRCA1...

Topics

• BRCA1 Protein
• Female
• Humans
• Mutation
• Risk Factors