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Aging and anti-aging: Unexpected side effects of everyday medication through sirtuin1 modulation

1 Feb 2008

Abstract excerpt

The sirtuin 1 protein (SIRT1) is a member of the class III NAD+-dependent histone deacetylases, which are also referred to as the 'sirtuins'. The sirtuins and silent information regulator 1 (SIRT1) in particular, are known to play a role in the response to DNA damage, metabolism, longevity and carcinogenesis. SIRT1 regulates different cellular processes such as proliferation, differentiation and apoptosis through...

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PMID: 18204789
DOI: 10.3892/ijmm.21.2.223

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