Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy

2 May 2021

Abstract excerpt

, p53, and β-galactosidase, was associated with loss of Sirt6. However, Sirt6 overexpression protected cardiomyocytes from developing Dox-induced senescence. Further, compared to wild-type mice, the hearts of Sirt6.Tg mice showed reduced expression of aging markers, and the development of aging-associated cardiac hypertrophy and fibrosis. Our data suggest that Sirt6 is a critical anti-aging molecule that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Mitochondrial Function and Pathology
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33934090
DOI: 10.18632/aging.203027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophyPMID 33934090Read ↗

SIRT6 in Senescence and Aging-Related Cardiovascular DiseasesSemantic proximity Read ↗

A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic TargetsSemantic proximity Read ↗

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart FailureSemantic proximity Read ↗

SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and agingSemantic proximity Read ↗

SIRT1 and SIRT6: The role in aging-related diseasesSemantic proximity Read ↗

Targeting SIRT2 in Aging-Associated Fibrosis PathophysiologySemantic proximity Read ↗

Emerging beneficial roles of sirtuins in heart failureSemantic proximity Read ↗

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in miceSemantic proximity Read ↗

The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging PathomechanismsSemantic proximity Read ↗

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity‐mediated diabetic cardiomyopathySemantic proximity Read ↗

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-JunSemantic proximity Read ↗

Sirtuins: guardians of mammalian healthspan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.