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Article

DLL3 regulates Notch signaling in small cell lung cancer

16 Nov 2022

Abstract excerpt

Tumor heterogeneity plays a critical role in tumor development and response to treatment. In small-cell lung cancer (SCLC), intratumoral heterogeneity is driven in part by the Notch signaling pathway, which reprograms neuroendocrine cancer cells to a less/non-neuroendocrine state. Here we investigated the atypical Notch ligand DLL3 as a biomarker of the neuroendocrine state and a regulator of cell-cell...

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PMID: 36483011
DOI: 10.1016/j.isci.2022.105603

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