Article

Efficient Immune Cell Genome Engineering with Improved CRISPR Editing Tools

2020-02-14

Abstract excerpt

CRISPR (clustered regularly interspaced short palindromic repeats)-based methods have revolutionized genome engineering and the study of gene-phenotype relationships. However, modifying cells of the innate immune system, especially macrophages, has been challenging because of cell pathology and low targeting efficiency resulting from nucleic acid activation of sensitive intracellular sensors. Likewise, lymphocytes...

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Literature Corpus work: febe8290-164c-50e4-9c06-3de73bf3d513
DOI: 10.1101/2020.02.13.947002

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