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Article

SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis.

Cell death and differentiation - 1 Feb 2023

Gao Kun, Shi Qing, Gu Ye, Yang Wanqi, He Yuanlong, Lv Zeheng, Ding Yan, Cao Wenxin, Wang Chenji, Wan Xiaoping

Abstract excerpt

Blockade of programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) has evolved into one of the most promising immunotherapy strategies for cancer patients. Tumor cells frequently overexpress PD-L1 to evade T cell-mediated immune surveillance. However, the specific genetic alterations that drive aberrant overexpression of PD-L1 in cancer cells remain poorly understood. The gene encoding the E3...

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Source

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Identifiers

PMID: 36481790
DOI: 10.1038/s41418-022-01097-7
PMCID: PMC9950446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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