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LATS1/2 Loss Promote Tumor Immune Evasion in Endometrial Cancer through Downregulating MHC-I Expression

2023-11-07

Abstract excerpt

<h4>Background: </h4> LATS1/2 are frequently mutated and down-regulated in endometrial cancer (EC), but the contributions of LATS1/2 in EC progression remains unclear. Impaired antigen presentation due to mutations or downregulation of the major histocompatibility complex class I (MHC-I) has been implicated in tumor immune evasion. Herein, we elucidate the oncogenic role that dysregulation of LATS1/2 in EC leads t...

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Literature Corpus work
57fa7545-e0f3-5160-8eae-135e7fdd0a18
DOI
10.21203/rs.3.rs-3507155/v1
Open publication

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LATS1/2 Loss Promote Tumor Immune Evasion in Endometrial Cancer through Downregulating MHC-I ExpressionDOI 10.21203/rs.3.rs-3507155/v1
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