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The role of next-generation sequencing in the examination of signaling genes in Brca1/2-negative breast cancer cases.

Annals of human genetics - 1 Mar 2023

Cine Naci, Ugurtas Cansu, Gokbayrak Merve, Aydin Duygu, Demir Gulhan, Kuru Seda, Sunnetci-Akkoyunlu Deniz, Eren-Keskin Seda, Simsek Turgay, Cabuk Devrim, Aksu Maksut Gorkem, Canturk Nuh Zafer, Savli Hakan

Abstract excerpt

INTRODUCTION: Breast cancer is the most prevalent malignancy in women worldwide. Although pathogenic variants in the BRCA1/2 genes are responsible for the majority of hereditary breast cancer cases, a substantial proportion of patients are negative for pathogenic variations in these genes. In cancers, the signal transduction pathways of the cell are usually affected first. Therefore, this study aimed to detect...

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PMID: 36479692
DOI: 10.1111/ahg.12488

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