Genetic risk scores and dementia risk across different ethnic groups in UK Biobank

Abstract excerpt

BACKGROUND: Genetic Risk Scores (GRS) for predicting dementia risk have mostly been used in people of European ancestry with limited testing in other ancestry groups. METHODS: We conducted a logistic regression with all-cause dementia as the outcome and z-standardised GRS as the exposure across diverse ethnic groups. FINDINGS: There was variation in frequency of APOE alleles across ethnic groups. Per standard...

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