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Article

Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors.

eLife - 8 Dec 2022

Kang Minsu, Na Hee Young, Ahn Soomin, Kim Ji-Won, Lee Sejoon, Ahn Soyeon, Lee Ju Hyun, Youk Jeonghwan, Kim Haesook T, Kim Kui-Jin, Suh Koung Jin, Lee Jun Suh, Kim Se Hyun, Kim Jin Won, Kim Yu Jung, Lee Keun-Wook, Yoon Yoo-Seok, Kim Jee Hyun, Chung Jin-Haeng, Han Ho-Seong, Lee Jong Seok

Abstract excerpt

We aimed to elucidate the evolutionary trajectories of gallbladder adenocarcinoma (GBAC) using multi-regional and longitudinal tumor samples. Using whole-exome sequencing data, we constructed phylogenetic trees in each patient and analyzed mutational signatures. A total of 11 patients including 2 rapid autopsy cases were enrolled. The most frequently altered gene in primary tumors was ERBB2 and TP53 (54.5%),...

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Identifiers

PMID: 36476508
DOI: 10.7554/eLife.78636
PMCID: PMC9771369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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