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Article

Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder.

Signal transduction and targeted therapy - 10 Feb 2021

Liu Fatao, Li Yongsheng, Ying Dongjian, Qiu Shimei, He Yong, Li Maolan, Liu Yun, Zhang Yijian, Zhu Qin, Hu Yunping, Liu Liguo, Li Guoqiang, Pan Weihua, Jin Wei, Mu Jiasheng, Cao Yang, Liu Yingbin

Abstract excerpt

Neuroendocrine carcinoma (NEC) of the gallbladder (GB-NEC) is a rare but extremely malignant subtype of gallbladder cancer (GBC). The genetic and molecular signatures of GB-NEC are poorly understood; thus, molecular targeting is currently unavailable. In the present study, we applied whole-exome sequencing (WES) technology to detect gene mutations and predicted somatic single-nucleotide variants (SNVs) in 15...

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Identifiers

PMID: 33563892
DOI: 10.1038/s41392-020-00412-3
PMCID: PMC7873252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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