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Article

Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer.

Nature communications - 6 Aug 2021

Lin Jianzhen, Peng Xinxin, Dong Kun, Long Junyu, Guo Xuejiao, Li Hongyue, Bai Yi, Yang Xu, Wang Dongxu, Lu Xin, Mao Yilei, Sang Xinting, Ji Xuwo, Zhao Haitao, Liang Han

Abstract excerpt

Gallbladder carcinoma is the most common cancer of the biliary tract with dismal survival largely due to delayed diagnosis. Biliary tract intraepithelial neoplasia (BilIN) is the common benign tumor that is suspected to be precancerous lesions. However, the genetic and evolutionary relationships between BilIN and carcinoma remain unclear. Here we perform whole-exome sequencing of coexisting low-grade BilIN...

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Identifiers

PMID: 34362903
DOI: 10.1038/s41467-021-25012-9
PMCID: PMC8346570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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