Article
Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma.
Human cell - 1 May 2021
Feng Feiling, Cheng Qingbao, Li Bin, Liu Chen, Wang Huizhen, Li Bin, Xu Xiaoya, Yu Yong, Chen Zishuo, Wu Xiaobing, Dong Hua, Chu Kaijian, Xie Zhenghua, Gao Qingxiang, Xiong Lei, Li Fugen, Yi Bin, Zhang Dadong, Jiang Xiaoqing
Abstract excerpt
Gallbladder carcinoma (GBC) is a lethal biliary tract malignant neoplasm. Patient-derived primary cancer cell lines (PDPCs) are appropriate models to explore biological characteristics and potential therapeutics; however, there is a lack of PDPCs in GBC. In this study, we aimed to establish and characterize the GBC PDPCs, and further investigated the intra-tumor heterogeneity (ITH). Multi-region sampling (3-9...
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