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Article

Deciphering Cancer Evolution Through Genomic Profiling of Patient-Derived Xenograft Together with Matched Primary Gallbladder Cancer.

Digestive diseases and sciences - 1 Apr 2026

Yadav Vipin, Kilambi Ragini, Rastogi Archana, Sharma Deepti, Nagarajan Perumal, Suroliya Varun, Bhattacharya Anupam, Yadav Vaishali, Gautam Pramod, Kashayp Manju, Kashyap Manoj Kumar, Garg Vanya, Kumari Anupama, Trehanpati Nirupama, Ramakrishna Gayatri

Abstract excerpt

BACKGROUND: Gallbladder cancer has a poor prognosis due to its aggressive nature and late detection. Adenosquamous subtypes are rare and poorly characterized at the molecular level. Patient-derived xenograft (PDX) models preserve tumor heterogeneity and support evolutionary studies. Longitudinal specimens-primary, metastatic, and PDX-from the same patient, combined with immunohistochemistry (IHC), allow...

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Identifiers

PMID: 41207908
DOI: 10.1007/s10620-025-09471-4

Genes

KRAS
LRP1B
AQP1
ARID1A
ARID2
BAP1
CRP
PIK3CA
S100P

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Provenance

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