Integrative molecular characterisation of gallbladder cancer reveals micro-environment-associated subtypes.

doi:10.1016/j.jhep.2020.11.033

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Article

Integrative molecular characterisation of gallbladder cancer reveals micro-environment-associated subtypes.

Journal of hepatology - 1 May 2021

Nepal Chirag, Zhu Bin, O'Rourke Colm J, Bhatt Deepak Kumar, Lee Donghyuk, Song Lei, Wang Difei, Van Dyke Alison L, Choo-Wosoba Hyoyoung, Liu Zhiwei, Hildesheim Allan, Goldstein Alisa M, Dean Michael, LaFuente-Barquero Juan, Lawrence Scott, Mutreja Karun, Olanich Mary E, Lorenzo Bermejo Justo, Ferreccio Catterina, Roa Juan Carlos, Rashid Asif, Hsing Ann W, Gao Yu-Tang, Chanock Stephen J, Araya Juan Carlos, Andersen Jesper B, Koshiol Jill

Abstract excerpt

BACKGROUND & AIMS: Gallbladder cancer (GBC) is the most common type of biliary tract cancer, but the molecular mechanisms involved in gallbladder carcinogenesis remain poorly understood. In this study, we applied integrative genomics approaches to characterise GBC and explore molecular subtypes associated with patient survival. METHODS: We profiled the mutational landscape of GBC tumours (whole-exome sequencing...

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Identifiers

PMID: 33276026
DOI: 10.1016/j.jhep.2020.11.033
PMCID: PMC8058239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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