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Role of Warfarin Pharmacogenetic Testing in Clinical Practice

1 Mar 2010

Abstract excerpt

Chronic oral anticoagulation with warfarin is difficult to maintain within the therapeutic range and requires frequent monitoring and dose adjustments. Variations in two genes, VKORC1 and CYP2C9, have been associated with variation in warfarin metabolism among individuals. Patients with CYP2C9*2 and *3 variants have longer times to dose stabilization and are at higher risk of serious and life-threatening...

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PMID: 20402581
DOI: 10.2217/pgs.10.8

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