Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing

6 Dec 2022

Abstract excerpt

The glycolytic enzyme, pyruvate kinase Pyk1 maintains telomere heterochromatin by phosphorylating histone H3T11 (H3pT11), which promotes SIR (silent information regulator) complex binding at telomeres and prevents autophagy-mediated Sir2 degradation. However, the exact mechanism of action for H3pT11 is poorly understood. Here, we report that H3pT11 directly inhibits Dot1-catalyzed H3K79 tri-methylation (H3K79me3)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36473858
DOI: 10.1038/s41467-022-35182-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencingPMID 36473858Read ↗

Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylationSemantic proximity Read ↗

The INO80 Chromatin Remodeler Sustains Metabolic Stability by Promoting TOR Signaling and Regulating Histone AcetylationSemantic proximity Read ↗

Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism.Semantic proximity Read ↗

Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancerSemantic proximity Read ↗

MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostatSemantic proximity Read ↗

H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cellsSemantic proximity Read ↗

Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cellsSemantic proximity Read ↗

Protein methylation functions as the posttranslational modification switch to regulate autophagySemantic proximity Read ↗

Tel2 regulates the stability of PI3K-related protein kinases.Semantic proximity Read ↗

The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae.Semantic proximity Read ↗

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read ↗

PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.