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Article

Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish.

Disease models & mechanisms - 1 Jan 2023

Montal Emily, Lumaquin Dianne, Ma Yilun, Suresh Shruthy, White Richard M

Abstract excerpt

Obesity is a rising concern and associated with an increase in numerous cancers, often in a sex-specific manner. Preclinical models are needed to deconvolute the intersection between obesity, sex and melanoma. Here, we generated a zebrafish system that can be used as a platform for studying these factors. We studied how germline overexpression of Agrp along with a high-fat diet affects melanomas dependent on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 36472402
DOI: 10.1242/dmm.049671
PMCID: PMC9884122

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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