The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

doi:10.1186/gb-2013-14-10-r113

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Article

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

Genome biology - 1 Jan 2013

Yen Jennifer, White Richard M, Wedge David C, Van Loo Peter, de Ridder Jeroen, Capper Amy, Richardson Jennifer, Jones David, Raine Keiran, Watson Ian R, Wu Chang-Jiun, Cheng Jiqiu, Martincorena Iñigo, Nik-Zainal Serena, Mudie Laura, Moreau Yves, Marshall John, Ramakrishna Manasa, Tarpey Patrick, Shlien Adam, Whitmore Ian, Gamble Steve, Latimer Calli, Langdon Erin, Kaufman Charles, Dovey Mike, Taylor Alison, Menzies Andy, McLaren Stuart, O'Meara Sarah, Butler Adam, Teague Jon, Lister James, Chin Lynda, Campbell Peter, Adams David J, Zon Leonard I, Patton E Elizabeth, Stemple Derek L, Futreal P Andy

Abstract excerpt

BACKGROUND: Melanoma is the most deadly form of skin cancer. Expression of oncogenic BRAF or NRAS, which are frequently mutated in human melanomas, promote the formation of nevi but are not sufficient for tumorigenesis. Even with germline mutated p53, these engineered melanomas present with varia...

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Identifiers

PMID: 24148783
DOI: 10.1186/gb-2013-14-10-r113
PMCID: PMC3983654

Genes

BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24148783-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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