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Article

Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish.

PloS one - 10 Dec 2010

Santoriello Cristina, Gennaro Elisa, Anelli Viviana, Distel Martin, Kelly Amanda, Köster Reinhard W, Hurlstone Adam, Mione Marina

Abstract excerpt

BACKGROUND: Melanoma is the most aggressive and lethal form of skin cancer. Because of the increasing incidence and high lethality of melanoma, animal models for continuously observing melanoma formation and progression as well as for testing pharmacological agents are needed. METHODOLOGY AND PRINCIPAL FINDINGS: Using the combinatorial Gal4-UAS system, we have developed a zebrafish transgenic line that expresses...

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Identifiers

PMID: 21170325
DOI: 10.1371/journal.pone.0015170
PMCID: PMC3000817

Genes

HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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