Article
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
Current biology : CB - 8 Feb 2005
Patton E Elizabeth, Widlund Hans R, Kutok Jeffery L, Kopani Kamden R, Amatruda James F, Murphey Ryan D, Berghmans Stephane, Mayhall Elizabeth A, Traver David, Fletcher Christopher D M, Aster Jon C, Granter Scott R, Look A Thomas, Lee Charles, Fisher David E, Zon Leonard I
Abstract excerpt
Melanoma is the most lethal form of skin cancer, and the incidence and mortality rates are rapidly rising. Epidemiologically, high numbers of nevi (moles) are associated with higher risk of melanoma . The majority of melanomas exhibit activating mutations in the serine/threonine kinase BRAF . BRAF mutations may be critical for the initiation of melanoma ; however, the direct role of BRAF in nevi and melanoma has...
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