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Article

Echoed induction of nucleotide variants and chromosomal structural variants in cancer cells.

Scientific reports - 5 Dec 2022

Matsuno Yusuke, Kusumoto-Matsuo Rika, Manaka Yuya, Asai Haruka, Yoshioka Ken-Ichi

Abstract excerpt

Generally, the number of single-nucleotide variants (SNVs) in somatic cells increases with age, which is expected for replication errors. The number of SNVs in cancer cells, however, is often much higher than that in somatic cells, raising the question of whether cancer cells possess SNV induction pathways. The present study shows that the number of SNVs in cancer cells correlates with the number of chromosomal...

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PMID: 36470958
DOI: 10.1038/s41598-022-25479-6
PMCID: PMC9723101

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