Article
DQA1*0102 DQB1*0602 haplotype distinguishes coeliac disease and its complications from gluten unrelated enteropathies.
European journal of gastroenterology & hepatology - 1 Jan 2023
De Silvestri Annalisa, Schiepatti Annalisa, Fowler Bryce D, Badulli Carla, Belvisi Fabrizio, Cacciatore Rosalia, Pasi Annamaria, Zingone Fabiana, Goodwin John, Key Tim, Rej Anupam, Sanders David S, Biagi Federico
Abstract excerpt
BACKGROUND: Duodenal villous atrophy is due not only to coeliac disease and its complications but also to other rare enteropathies unrelated to gluten consumption, defined as noncoeliac enteropathies. The diagnosis of noncoeliac enteropathies remains challenging, and HLA typing has been widely used to exclude coeliac disease if DQ2 and DQ8 alleles are absent. However, the frequency of the various HLA alleles in...
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