Article
How to diagnose coeliac disease in 2026?
Minerva gastroenterology - 1 Mar 2026
Manza Francesca, Sammartino Camilla, Nandi Nicoletta, Markogiannopoulou Aikaterini, Lungaro Lisa, Shiha Mohamed G
Abstract excerpt
Coeliac disease (CD) is a chronic, immune-mediated enteropathy triggered by gluten ingestion in genetically predisposed individuals carrying HLA-DQ2 and/or -DQ8 alleles. Its diagnosis traditionally combines serology and confirmatory duodenal biopsy. IgA anti-tissue transglutaminase is the first-line test, supported by endomysial antibody. Duodenal histology remains the gold standard, though limitations include...
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