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Article

Presence of high-risk HLA genotype is the most important individual risk factor for coeliac disease among at-risk relatives.

Alimentary pharmacology & therapeutics - 1 Sept 2021

Paavola Saana, Lindfors Katri, Kivelä Laura, Cerqueira Juliana, Huhtala Heini, Saavalainen Päivi, Tauschi Riku, Kaukinen Katri, Kurppa Kalle

Abstract excerpt

BACKGROUND: Family screening has been advocated as a means to reduce the major underdiagnosis of coeliac disease. However, the precise risk of the disease in relatives and the impact of patient- and relative-related individual factors remain obscure. AIMS: To investigate the individual risk of coeliac disease among patients' relatives. METHODS: Altogether 2943 relatives of 624 index patients were assessed for the...

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PMID: 34278595
DOI: 10.1111/apt.16534

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