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Article

Role of pericytes in the development of cerebral cavernous malformations

19 Nov 2022

Abstract excerpt

Cerebral cavernous malformation (CCM) is caused by loss-of-function mutations in CCM1 , CCM2 , or CCM3 genes of endothelial cells. It is characterized by pericyte deficiency. However, the role of pericytes in CCMs is not yet clarified. We found pericytes in Cdh5Cre ERT2 ; Ccm1 fl/fl ( Ccm1 ECKO ) mice had a high expression of PDGFRβ. The inhibition of pericyte function by CP-673451 aggravated the CCM lesion...

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PMID: 36465134
DOI: 10.1016/j.isci.2022.105642

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