Article
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
EMBO molecular medicine - 1 Jan 2016
Cuttano Roberto, Rudini Noemi, Bravi Luca, Corada Monica, Giampietro Costanza, Papa Eleanna, Morini Marco Francesco, Maddaluno Luigi, Baeyens Nicolas, Adams Ralf H, Jain Mukesh K, Owens Gary K, Schwartz Martin, Lampugnani Maria Grazia, Dejana Elisabetta
Abstract excerpt
Cerebral cavernous malformations (CCMs) are vascular malformations located within the central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is needed, since current therapy is limited to neurosurgery. Familial CCM is caused by loss-of-function mutations in any o...
Topics
- Animals
- Bone Morphogenetic Protein 6
- Cell Proliferation
- Disease Models, Animal
- Disease Progression
- Endothelial Cells
- HEK293 Cells
- Hemangioma, Cavernous, Central Nervous System
- Humans
- KRIT1 Protein