Article
Genetic mutations underlying isoniazid-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2023
Khan Anwar Sheed, Phelan Jody E, Khan Muhammad Tahir, Ali Sajid, Qasim Muhammad, Mohammad Noor, Napier Gary, Ahmad Sajjad, Alam Jamshed, Khattak Baharullah, Campino Susana, Clark Taane G, Khan Taj Ali
Abstract excerpt
Tuberculosis, caused by Mycobacterium tuberculosis, is a major public health issue in Pakistan. Isoniazid is a first-line pro-drug that requires activation through an enzyme called catalase peroxidase, but is subject to widespread resistance, driven by mutations in katG and inhA genes and other loci with compensatory effects (e.g., ahpC). Here, we used whole genome sequencing data from 51 M. tuberculosis isolates...
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