Back to search

Article

A thermophilic Cas13 enzyme for sensitive and specific one-pot detection of SARS-CoV-2

2021-09-22

Abstract excerpt

<title>Abstract</title> <p>Robust, sensitive, and specific diagnostic platforms for early pathogen detection are essential for the identification of infected patients and management of current and future pandemics. CRISPR-Cas systems have been repurposed for SARS-CoV-2 detection in two-pot assays. Two-pot assays require extra steps and are prone to cross-contamination; however, the temperature range of current Ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9a0d06c9-9d53-5a04-87ff-764b7720a831
DOI
10.21203/rs.3.rs-604849/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A thermophilic Cas13 enzyme for sensitive and specific one-pot detection of SARS-CoV-2DOI 10.21203/rs.3.rs-604849/v1
Characterization of a thermostable Cas13 enzyme for one-pot detection of SARS-CoV-2Semantic proximity
A Thermostable Cas12b from<i>Brevibacillus</i>Leverages One-pot Detection of SARS-CoV-2 Variants of ConcernSemantic proximity
A Combinatorial Approach towards Adaptability of 22 Functional Cas12a Orthologs for Nucleic Acid Detection in Clinical SamplesSemantic proximity
A Thermostable Cas12b from <i>Brevibacillus</i> Leverages One-Pot Discrimination of SARS-CoV-2 Variants of ConcernSemantic proximity
SATCAS: A CRISPR/Cas13a-based simultaneous amplification and testing platform for one-pot RNA detection and SNPs distinguish in clinical diagnosis.Semantic proximity
Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assaySemantic proximity
A multiplexed Cas13-based assay with point-of-care attributes for simultaneous COVID-19 diagnosis and variant surveillanceSemantic proximity
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant SurveillanceSemantic proximity
Virus detection via programmable Type III-A CRISPR-Cas systemsSemantic proximity
iSCAN-V2: A One-Pot RT-RPA–CRISPR/Cas12b Assay for Point-of-Care SARS-CoV-2 DetectionSemantic proximity
Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolutionSemantic proximity
Intrinsic signal amplification by type III CRISPR-Cas systems provides a sequence-specific SARS-CoV-2 diagnosticSemantic proximity
Select a neighboring publication to make it the new centre.