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Article

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments.

Nature cell biology - 1 Feb 2017

Fluegen Georg, Avivar-Valderas Alvaro, Wang Yarong, Padgen Michael R, Williams James K, Nobre Ana Rita, Calvo Veronica, Cheung Julie F, Bravo-Cordero Jose Javier, Entenberg David, Castracane James, Verkhusha Vladislav, Keely Patricia J, Condeelis John, Aguirre-Ghiso Julio A

Abstract excerpt

Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC and breast primary tumour microenvironments displayed upregulation of key dormancy (NR2F1, DEC2, p27) and hypoxia (GLUT1, HIF1α) genes. Analysis of solitary DTCs in PDX and transgenic mice revealed that...

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Identifiers

PMID: 28114271
DOI: 10.1038/ncb3465
PMCID: PMC5342902

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